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Strength points and limitations Based on our knowledge, this is the most updated meta-analysis on this topic, including all available evidence based on our inclusion criteria of including only controlled studies, either RCTs or controlled observational studies, to reach the highest accessible quality of evidence from the available evidence found in the literature

Understanding these mechanisms is critical before evaluating specific protocols

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33(7): 51724 Newman LC, Lay CL, OConnor KA, et al

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